AANP Practice Test 2026 – Comprehensive Exam Prep

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If the initial Lyme disease EIA/ELISA test is negative, what is recommended?

Repeat the ELISA test immediately

Start antibiotics anyway

Perform PCR testing

No further testing is recommended

Lyme disease testing uses a two-step approach: a screening EIA/ELISA first, and a confirmatory test (Western blot) only if the screening is positive. If the initial ELISA is negative, the testing algorithm does not proceed to confirmatory testing because a negative screen makes the diagnosis unlikely and the confirmatory test would not change management. Therefore, no further testing is recommended.

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