Acute gout management may include NSAIDs and which medication, commonly given at a 1.2 mg initial dose?

Acute gout management may include NSAIDs and which medication, commonly given at a 1.2 mg initial dose?

• A. Allopurinol
• B. Prednisone
• C. Naproxen
• D. Colchicine

Answer: (D)

Colchicine is used for acute gout flares as an anti-inflammatory alongside NSAIDs. The typical initial dose for an attack is 1.2 mg (two 0.6 mg tablets) taken at onset, then a smaller dose after about an hour if symptoms continue. It works by inhibiting microtubule formation in neutrophils, which reduces their migration and inflammatory activity in the joint. Allopurinol is for long-term urate lowering and isn’t used to treat an acute flare. Prednisone is an alternative if NSAIDs or colchicine aren’t suitable. Naproxen is the NSAID itself, not the additional agent given in this 1.2 mg initial-dose pattern.

Colchicine is used for acute gout flares as an anti-inflammatory alongside NSAIDs. The typical initial dose for an attack is 1.2 mg (two 0.6 mg tablets) taken at onset, then a smaller dose after about an hour if symptoms continue. It works by inhibiting microtubule formation in neutrophils, which reduces their migration and inflammatory activity in the joint. Allopurinol is for long-term urate lowering and isn’t used to treat an acute flare. Prednisone is an alternative if NSAIDs or colchicine aren’t suitable. Naproxen is the NSAID itself, not the additional agent given in this 1.2 mg initial-dose pattern.