Which symptom is most commonly associated with infectious mononucleosis due to EBV?

Which symptom is most commonly associated with infectious mononucleosis due to EBV?

• A. Fever
• B. Rash
• C. Lymphadenopathy
• D. Hypotension

Answer: (C)

Infectious mononucleosis from Epstein-Barr virus often causes a strong immune reaction in lymphoid tissues, leading to prominent lymph node enlargement. This lymphadenopathy, especially in the neck, is a classic and defining feature as the body mounts a T-cell–mediated response against infected B cells, causing nodes to become tender and enlarged. Fever and fatigue are common accompanying symptoms, and a rash can appear if ampicillin is given, but low blood pressure isn’t typical. So the swollen lymph nodes best capture the characteristic presentation of EBV-related mononucleosis.

Infectious mononucleosis from Epstein-Barr virus often causes a strong immune reaction in lymphoid tissues, leading to prominent lymph node enlargement. This lymphadenopathy, especially in the neck, is a classic and defining feature as the body mounts a T-cell–mediated response against infected B cells, causing nodes to become tender and enlarged. Fever and fatigue are common accompanying symptoms, and a rash can appear if ampicillin is given, but low blood pressure isn’t typical. So the swollen lymph nodes best capture the characteristic presentation of EBV-related mononucleosis.